We are pleased to announce that our work on a “novel concept of Micro Patterned Micro Titer Plates Fabricated via UV-NIL for Automated Neuronal Cell Assay Read-Out” has been published in the special issue “Nanoimprint Lithography Technology and Applications” in Nanomaterials.
In this article we show how UV-nanoimprint lithography (UV-NIL) can be used to fabricate an open channel microfluidic device that helps separating neurons. Details about the complete manufacturing process, from mastering to fabrication in small batches and in high throughput with up to 1200 micro titer plates per hour is presented. One of our imprint materials, the mr-UVCur26SF, has been used as the permanent material for the neuronal device. Deep insights into the cytotoxic evaluation, cell compatibility tests and finally a neuronal assay are given. The results indicate how the given pattern, in combination with the resist, paves the way to faster, cheaper, and more reliable drug screening.
This work perfectly bridges our research effort from the finished “R2RBiofludics”-Project to the “NextGenMicrofluidics”-Project (both Horizon 2020 funded) and aligns itself with our former publications on the fabrication of hierarchical patterned polymer masters and the high throughput fabrication of polymer biochips.
Link to the publication: https://doi.org/10.3390/nano11040902